Catalyst Biosciences


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Nassim Usman, Ph.D., President and Chief Executive Officer

Dr. Usman is currently President and CEO and a member of the Board of Directors at Catalyst Biosciences. Dr. Usman joined Catalyst from Morgenthaler Ventures, where he is a Venture Partner. Prior to joining Morgenthaler in 2005, he was Senior Vice President and Chief Operating Officer at Sirna Therapeutics Inc. (Nasdaq:RNAI – acquired by Merck NYSE:MRK) from 2004 to 2005 and held various R&D positions at both Sirna and Ribozyme Pharmaceuticals (Nasdaq:RZYM), including VP of R&D and Chief Scientific Officer, from 1992 to 2004. During his industrial career Dr. Usman has entered several drugs into clinical development, completed multiple licensing deals with pharmaceutical and biotechnology companies and raised capital in both private and public financings. Prior to moving into the biotechnology industry in 1992, Dr. Usman was an NIH Fogarty and NSERC Postdoctoral Fellow and Scientist in the Departments of Biology and Chemistry at the Massachusetts Institute of Technology from 1987 to 1992. He has authored more than 70 scientific articles and 130 patents and applications. Dr. Usman serves on the Boards of Mosaic Biosciences, Principia Biopharma and Osprey Pharmaceuticals, is a past director of Archemix Corporation (Cambridge, MA) and atugen AG (now Silence Therapeutics, LSE/AIM:SLN) and served on the SABs of RXi Pharmaceuticals and Noxxon Pharma AG. He received his B.Sc. (Honours) and Ph.D. in Organic Chemistry from McGill University. In his doctoral dissertation he developed a method for the solid-phase synthesis of RNA that is widely used in science and in a marketed RNA product (Macugen™).

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Edwin L. Madison, Ph.D., Chief Scientific Officer

Dr. Madison received a Ph.D. in biochemistry from University of Texas - Southwestern Medical Center (UTSWC) in 1990. Following graduation, Dr. Madison accepted a faculty position at UTSWC with joint appointments in the Departments of Biochemistry and Internal Medicine. Dr. Madison then moved to The Scripps Research Institute as an Associate Professor of Vascular Biology. Prior to moving to Catalyst Biosciences, Dr. Madison was Vice President of Biological Research at Dendreon San Diego and Dendreon Corporation, Professor of Vascular Biology at the Torrey Pines Institute for Molecular Studies, and Adjunct Professor of Vascular Biology at The Scripps Research Institute. Dr. Madison has achieved an international reputation in the fields of serine protease and serpin basic research, and he is one of the lead inventors of a currently marketed protease therapeutic agent.


Fletcher Payne, CFO

Fletcher Payne has spent over 20 years helping life science companies achieve their business goals. In his role as CFO, he has focused on raising capital, developing strategic financial plans, managing business growth, implementing corporate partnerships, managing business performance, and revenue management. His life science experience includes successful start-ups, IPOs, mergers, spin-outs, and working with R&D teams whose efforts have led to four products receiving FDA clearance. His company experiences include CytomX, Pathwork Diagnostics, Plexxikon, Rinat Neuroscience, Dynavax Technologies, Cell Genesys, Abgenix, Sun Micro Systems, and IBM. Mr. Payne is a graduate of the Walter A. Haas School of Business at the University of California, Berkeley.